The fifth-year residents return for the first day of a year that will make or break their careers: Meredith faces the consequences of tampering with Derek's clinical trial and is terminated at the hospital; April tries to step up to the plate as Chief Resident in the wake of a giant sinkhole in the middle of Seattle; and Cristina and Owen are still at odds over their drastically different feelings for their unborn child.

　　The staff tries to deal with physical and emotional trauma in the wake of the deadly rampage.

　　北京时间9月25日，ABC电视台重磅医务剧将以两小时特别篇回到我们的视线，上一季结尾留下的Izzie和George的去留问题将在回归篇中一一解答。感谢KatherineHeigl的直言，我们已经大概得知剧中这两位主要人物的命运。Izzie将会幸存下来，而George将告别观众。而且因为TRKnight的合同问题，George可能将不会再以新镜头出现在第六季中，开篇也仅仅将以一具棺材代替他的存在。ABC电视台也确认George的扮演者TR Knight将不会成为第六季的常规演员，与之相反的是扮演儿科医生的Arizona Robbins的JessicaCapshaw将有幸成为第六季的常规演员。可以预见，其与剧中另一主要角色Callie的同性恋情的戏份也将加长。

　　Recipient of the 2007 Golden Globe Award for Best Drama Television Series and multiple Emmy nominations, including Outstanding Drama Series for the past two years, "Grey's Anatomy" returns to the ABC Television Network for its fifth season.
　　Is "happily ever after" possible for Meredith Grey and Derek "McDreamy" Shepherd? With Meredith experiencing a breakthrough in therapy - the realization that she and Derek can be extraordinary together, rather than ordinary apart -- she and Derek now face the highs and lows of being a committed couple.
　　Continuing their first year as residents at Seattle Grace Hospital, Meredith, Cristina Yang, Izzie Stevens and Alex Karev have interns of their own to mentor, including Meredith's half-sister, Lexie Grey. Lexie has become a roommate and confidante to George O'Malley, who, after divorce with Callie, a breakup with Izzie, and learning that he failed his residency test by only one point, is striving to get both his professional and personal life back on track.
　　After attending to his girlfriend Rebecca's mental illness on his own, and revealing that he had gone through this with his own mother, Alex finds solace in Izzie's arms. Alex must continue through this difficult time, whether or not Izzie remains by his side.
　　Cristina, having finally won out over her tough-as-nails mentor, Erica, is back on track as a surgeon - but is there a chance for new love in her life as well?
　　With the encouragement of Mark "McSteamy" Sloan, Dr. Callie Torres has taken a chance on love with cardiothoracic surgeon, Erica Hahn; now, she and Erica must figure out what happens after the first kiss.
　　Overseeing the residents is the no-nonsense Chief Resident, Miranda Bailey. Facing marital troubles and the difficulty of balancing her work and personal life, Bailey has handed her responsibilities as head of the free clinic over to Izzie. Also striving for balance is Chief of Surgery, Richard Webber, who has reunited with his estranged wife, Adele.
　　The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis - it's in one another that they find comfort, friendship and love. Together they're discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.
　　"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, and Brooke Smith as Erica Hahn.

　　由《绯闻女孩》两位主创Josh Schwartz和Stephanie Savage在Apple TV+开发的新剧《焰火之城》（City On Fire）定档5月12日开播。这部八集组成的剧集将在首播周更新三集，此后逢周五更新一集，于6月16日季终。
　　这是Josh和Stephanie早前与该流媒体签订优先合作条约的首个项目。与《绯闻女孩》相似，故事同样改编自同名小说，Garth Risk Hallberg所著的小说讲述了在2003年的7月4日，年轻女孩“Samantha Cicciaro”在纽约中央公园被枪击，当时所有人都在观看烟火，所以没有证人也没有太多物证。
　　而事发前她正在她最爱的夜店看着她朋友乐队的表演，临时出去见朋友却再也没有回来。随着警方调查的深入，所有人都惊讶的发现她不仅连接着纽约下城的音乐圈子，还和上东区的富有的地产家族有着紧密联系。
　　在《性 教育》完成“Hope”演出的Jemima Kirke饰演“Regan”，她是曼哈顿地产大亨的女儿，但努力想要靠自己取得成功；而《继承之战》“Nate” Ashley Zukerman饰演她的丈夫“Keith”，他的魅力帮助他失败后重新站起来。
　　《年轻一代》“Josh” Nico Tortorella饰演“William”，才华横溢、但却自我毁灭的艺术家；而Xavier Clyde则饰演他的男朋友“Mercer”，从乔治亚州农村来到纽约的他，写下了一本杰出的小说，并拥抱真实的自己。
　　歌手，出演了《劣迹斑斑》的Max Milner饰演“Nicky Chaos”，一个充满魅力的活动家，也和一群朋友致力于同精英主义进行斗争；而《实习医生格蕾》十六季做短暂演出的“Cindy”Alexandra Doke饰演的“Sewer Girl”，就是这个团队的主力成员。
　　《曼达洛人》“Dr.Pershing” Omid Abtahi饰演的“Ali Parsa”，是负责调查Samantha遇害的侦探；而《港湾》“Audrey” Kathleen Munroe则是与他搭档的“PJ McFadden”；至于此前在《乔对决卡萝尔》完成“Joe Exotic”演出的John Cameron Mitchell则饰演“Amory”，是曼哈顿一名具有影响力和权势的高管，他为人无情但也同样迷人。

　　由年轻喜剧演员与老牌明星联合主演，《硅谷》叙说着一位住在“骇客旅社”的内向电脑工程师与他朋友们的故事。这群不太能融入社会的家伙被一位网路公司的百万富翁“关照”着，他允许这群工程师免费住在他的房子，不过条件是要取得他们专案的10%股份。